Once a jolly pyruvate enters the matrix
Of a mitochondrion, so they say,
A decarboxylating, complex dehydrogenase
Converts it to acetyl co-enzyme A.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle today.
A decarboxylating, complex dehydrogenase
Turns pyruvate to acetyl CoA.
Oxaloacetate looking for a partner
Thinks "active acetate" looks OK;
Citrate sythase arranging the merger
Makes a new citrate, and kicks out CoA.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle today
Citrate sythase arranging the merger
Makes a new citrate, and kicks out CoA.
Along comes aconitase, a hydro-dehydratase,
Gives isocitrate reversibly.
Then its dehydrogenase gives NADH,
Carbon dioxide and α-KG.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle with me
Then its dehydrogenase gives NADH,
Carbon dioxide and α-KG.
Off with the CO2. Another oxidation
Just like the PDC previously.
Succinyl CoA with a synthatase
Yields succinate and GTP.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle with me
Succinyl CoA with a synthatase
Yields succinate and GTP.
Succinate's oxidized by its dehydrogenase
Reducing FAD, giving fumarate;
Fumarase makes malate; another dehydrogenase
Regenerates Oxaloacetate.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle, mate
Fumarase makes malate; another dehydrogenase
Regenerates Oxaloacetate.
Waltz Round the Cycle
Once a jolly pyruvate enters the matrix
Of a mitochondrion, so they say,
A decarboxylating, complex dehydrogenase
Converts it to acetyl co-enzyme A.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle today.
A decarboxylating, complex dehydrogenase
Turns pyruvate to acetyl CoA.
Oxaloacetate looking for a partner
Thinks "active acetate" looks OK;
Citrate sythase arranging the merger
Makes a new citrate, and kicks out CoA.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle today
Citrate sythase arranging the merger
Makes a new citrate, and kicks out CoA.
Along comes aconitase, a hydro-dehydratase,
Gives isocitrate reversibly.
Then its dehydrogenase gives NADH,
Carbon dioxide and α-KG.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle with me
Then its dehydrogenase gives NADH,
Carbon dioxide and α-KG.
Off with the CO2. Another oxidation
Just like the PDC previously.
Succinyl CoA with a synthatase
Yields succinate and GTP.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle with me
Succinyl CoA with a synthatase
Yields succinate and GTP.
Succinate's oxidized by its dehydrogenase
Reducing FAD, giving fumarate;
Fumarase makes malate; another dehydrogenase
Regenerates Oxaloacetate.
Waltz round the cycle
Waltz round the cycle
Waltz round the TCA cycle, mate
Fumarase makes malate; another dehydrogenase
Regenerates Oxaloacetate.
Abbreviations: